Journal
CANCER LETTERS
Volume 402, Issue -, Pages 9-15Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.05.001
Keywords
Bacteria; Cholangiocarcinoma; Gut-liver axis; Hepatocellular carcinoma; Pancreatic adenocarcinoma
Categories
Funding
- Takeda Science Foundation
- KANAE Foundation for the Promotion of Medical Science
- YOKOYAMA Foundation for Clinical Pharmacology
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [16K10504] Funding Source: KAKEN
Ask authors/readers for more resources
The human intestinal microbiome encompasses at least 100 trillion microorganisms that can influence host immunity and disease conditions, including cancer. Hepatobiliary and pancreatic cancers have been associated with poor prognosis owing to their high level of tumor invasiveness, distant metastasis, and resistance to conventional treatment options, such as chemotherapy. Accumulating evidence from animal models suggests that specific microbes and microbial dysbiosis can potentiate hepatobiliary-pancreatic tumor development by damaging DNA, activating oncogenic signaling pathways, and producing tumor-promoting metabolites. Emerging evidence suggests that the gut microbiota may influence not only the efficacy of cancer chemotherapies and novel targeted immunotherapies such as anti-CTIA4 and anti-CD274 therapies but also the occurrence of postoperative complications after hepatobiliary and pancreatic surgery, which have been associated with tumor recurrence and worse patient survival in hepatobiliary-pancreatic cancers. Hence, a better understanding of roles of the gut microbiota in the development and progression of hepatobiliary-pancreatic tumors may open opportunities to develop new prevention and treatment strategies for patients with hepatobiliary-pancreatic cancer through manipulating the gut microbiota by diet, lifestyle, antibiotics, and pro- and prebiotics. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available