Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 25, Issue 1, Pages 99-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2016.05.001
Keywords
Differential Scanning Calorimetry (DSC); Thermogravimetric analysis (TGA); Paracetamol; Chlorpheniramine maleate and phenylephrine hydrochloride
Categories
Funding
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
- CAPES (Coordenacao Aperfeic, oamento de Pessoal de Nivel Superior)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [443238/2014-6, 470388/2014-5]
- Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) [UID/QUI/50006/2013]
- FEDER
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Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1: 1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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