Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 34, Pages 28939-28948Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b09227
Keywords
preferred coordination strategy; open active sites; host-guest interaction; nano-MOFs; Zn2+-triggered drug release
Funding
- National Natural Science Foundation of China [21371040, 21571042]
- National Key Basic Research Program of China (973 Program) [2013CB632900]
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Drug delivery in target regions could make extraordinary progress in chemoselective therapies. A novel preferred coordination (PC) strategy referring to proactive interacting with open active sites to replace previous occupation by ion-exchange for controlling release of drug molecules is well-constructed. Two topological types of MOF-In1 (Schlafli symbol: (4,8)-connected of (4(10).6(15).8(3))(4(5).6)(2)) and MOF-In2 (Schlafli symbol: (4,4)-connected of (6(6))) show the specific way. Increasing node connectivity as well as the trapping of guest OH- anions, 5-fluorouracil (5-FU) is preferentially captured into the MOF-In1, which exhibits an outstanding loading capacity around 34.32 wt %. F-19 NMR spectroscopy was further employed to investigate host-guest interaction and reveal the binding constant (K-a = 3.84 X 10(2) M-1). Meanwhile, the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution by biofriendly Zn2+-triggered is realized. With an elevated Zn2+ concentration, the drug release will be enhanced. This efficient strategy for MOFs as multifunctional drug carrier opens a new avenue for biological and medical applications.
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