Journal
BMC BIOLOGY
Volume 15, Issue -, Pages 1-1Publisher
BMC
DOI: 10.1186/s12915-017-0411-5
Keywords
-
Categories
Funding
- MRC
- ERC
- Wellcome Trust
- MRC [MC_UU_12008/1] Funding Source: UKRI
- Medical Research Council [MC_UU_12008/1] Funding Source: researchfish
Ask authors/readers for more resources
Strong DNA conservation among divergent species is an indicator of enduring functionality. With weaker sequence conservation we enter a vast 'twilight zone' in which sequence subject to transient or lower constraint cannot be distinguished easily from neutrally evolving, non-functional sequence. Twilight zone functional sequence is illuminated instead by principles of selective constraint and positive selection using genomic data acquired from within a species' population. Application of these principles reveals that despite being biochemically active, most twilight zone sequence is not functional.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available