Related references
Note: Only part of the references are listed.PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor
K. Bhattacharya et al.
ONCOGENESIS (2016)
Regulation of Endothelial Cell Proliferation and Vascular Assembly through Distinct mTORC2 Signaling Pathways
Shan Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Significance of filamin A in mTORC2 function in glioblastoma
Naphat Chantaravisoot et al.
MOLECULAR CANCER (2015)
Hedgehog Signaling Pathway Is Active in GBM with GLI1 mRNA Expression Showing a Single Continuous Distribution Rather than Discrete High/Low Clusters
Vikas Chandra et al.
PLOS ONE (2015)
Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma
Ranjita Das et al.
APOPTOSIS (2014)
Improved chemosensitivity in cervical cancer to cisplatin: Synergistic activity of mahanine through STAT3 inhibition
Ranjita Das et al.
CANCER LETTERS (2014)
mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
Kenta Masui et al.
CELL METABOLISM (2013)
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo
Sayantani Sarkar et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Mahanine, A DNA Minor Groove Binding Agent Exerts Cellular Cytotoxicity with Involvement of C-7-OH and -NH Functional Groups
Suman K. Samanta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice
Tariq Bashir et al.
PLOS ONE (2012)
mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
Pat Gulhati et al.
CANCER RESEARCH (2011)
Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
Yan Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways
Kaushik Bhattacharya et al.
BIOCHEMICAL PHARMACOLOGY (2010)
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
Hanna Tukachinsky et al.
JOURNAL OF CELL BIOLOGY (2010)
mTOR signaling in glioblastoma: lessons learned from bench to bedside
David Akhavan et al.
NEURO-ONCOLOGY (2010)
Glioblastoma multiforme: a review of where we have been and where we are going
Cory Adamson et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
Miao-Hsueh Chen et al.
GENES & DEVELOPMENT (2009)
A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma
Renee D. Read et al.
PLOS GENETICS (2009)
Hedgehog: functions and mechanisms
Markku Varjosalo et al.
GENES & DEVELOPMENT (2008)
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
Janine Masri et al.
CANCER RESEARCH (2007)
Role of GL12 transcription factor in growth and tumorigenicity of prostate cells
Saravanan Thiyagarajan et al.
CANCER RESEARCH (2007)
Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells
M. Ehtesham et al.
ONCOGENE (2007)
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
Virginie Clement et al.
CURRENT BIOLOGY (2007)
Targeting the Hedgehog pathway in cancer
Lee L. Rubin et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
mTOR and cancer: insights into a complex relationship
David M. Sabatini
NATURE REVIEWS CANCER (2006)
Gli2 is targeted for ubiquitination and degradation by β-TrCP ubiquitin ligase
Neehar Bhatia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
Y Pan et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
E Roessler et al.
HUMAN MOLECULAR GENETICS (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma
G Regl et al.
ONCOGENE (2002)
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1
MA Price et al.
CELL (2002)
Stem cells, cancer, and cancer stem cells
T Reya et al.
NATURE (2001)
Share Paper
