Journal
CELL DEATH & DISEASE
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2017.497
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Funding
- National Key Research and Development Program of China [2017YFC1001602, 2017YFA0106300, 2017YFA0102900, 2016YFA0100300, 2013CB967403]
- National Natural Science Foundation projects of China [U1601227, 31622037, 31631163001, 81570520, 31701281, 31701106, 31601176, 31601088]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSWSMC001]
- Guangzhou Health Care and Cooperative Innovation Major Project [201704020218, 201604020009]
- Guangdong Province Science and Technology Program [2015TX01R047, 2014TQ01R559, 2015A020212031, 2017A020215056]
- PhD Start-up Fund of Natural Science Foundation of Guangdong Province [2014A030310071]
- Guangzhou Science and Technology Program [201707020043, 201707010178]
- Yangtse River Scholar Bonus Schemes
- CAS Youth Innovation Promotion Association
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MicroRNAs (miRNAs) play crucial roles in the establishment of pluripotent state by controlling pluripotent network. However, the molecular mechanisms controlling miRNAs during somatic cell reprogramming remain obscure. In this study, we show Gadd45a (growth arrest and DNA-damage-inducible protein 45a) enhances reprogramming by activating miR-295. Furthermore, we show that Gadd45a binds the promoter regions of miR-295. Nuclease accessibility assay indicates that Gadd45a opens the promoter regions of miR-295. Levels of H3K9Ac and H3K27Ac on the promoter regions of miR-295 were also increased. In conclusion, our results indicate that Gadd45a relaxes the promoter regions of miR-295 and promotes the expression of miR-295 during reprogramming, implying a concise mechanism of Gadd45a and miR-290 cluster cooperation in cell-fate determination.
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