Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 94, Issue 1, Pages 67-70Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2014.11.001
Keywords
Neutrophils; MHC class II; NADPH oxidase; ROS
Categories
Funding
- Russian Foundation for Basic Research [14-04-00868]
Ask authors/readers for more resources
In response to selected cytokines, neutrophils are induced to express MHC class II and acquire properties of antigen-presenting cells. Here we show that (a) GM-CSF- and IFN-gamma-mediated induction of MHC class II in human neutrophils is associated with intracellular ROS up-regulation, (b) cell-permeable ROS scavengers MnTMPyP and polyethylene glycol-conjugated superoxide dismutase and NADPH oxidase inhibitors diphenylene iodonium and apocynin abrogate both the cytokine-mediated ROS elevation and the induction of MHC class II and (c) neutrophils from chronic granulomatous disease patients which lack NADPH oxidase activity fail to express MHC class II in response to the cytokines. Thus, NADPH oxidase activity is required for the cytokine-mediated induction of MHC class II expression in neutrophils. (C) 2014 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available