Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 94, Issue 12, Pages 547-563Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2015.08.002
Keywords
Sox gene; HMG box; Nucleocytoplasmic shuttling; Posttranslational modification; SOX-partner complex; Developmental function
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Funding
- National Natural Science Foundation of China [41276151]
- National Basic Research Program of China (973 Program) [2012CB967902]
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In metazoa, SOX family transcription factors play many diverse roles. In vertebrate, they are well-known regulators of numerous developmental processes. Wide-ranging studies have demonstrated the co-expression of SOX proteins in various developing tissues and that they occur in an overlapping manner and show functional redundancy. In particular, studies focusing on the HMG box of SOX proteins have revealed that the HMG box regulates DNA-binding properties, and mediates both the nucleocytoplasmic shuttling of SOX proteins and their physical interactions with partner proteins. Posttranslational modifications are further implicated in the regulation of the transcriptional activities of SOX proteins. In this review, we discuss the underlying molecular mechanisms involved in the SOX-partner factor interactions and the functional modes of SOX-partner complexes during development. We particularly emphasize the representative roles of the SOX group proteins in major tissues during developmental and physiological processes. (C) 2015 Elsevier GmbH. All rights reserved.
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