Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 9, Issue 11, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a022038
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Funding
- National Science Foundation [DMR-1310266]
- Harvard and Penn Materials Research Science and Engineering Centers [DMR-1420570, DMR-0520020]
- National Institutes of Health [P01HL120839, P01GM096971]
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The cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic biopolymer network comprising microtubules, actin, and intermediate filaments. Both the individual filaments and the entire network are not simple elastic solids but are instead highly nonlinear structures. Appreciating the mechanics of biopolymer networks is key to understanding the mechanics of cells. Here, we review the mechanical properties of cytoskeletal polymers and discuss the implications for the behavior of cells.
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