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JOURNAL OF BONE AND MINERAL RESEARCH (2006)
BMP-2 gene polymorphisms and osteoporosis:: The Rotterdam Study
Marco Medici et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2006)
The logic of TGFβ signaling
Joan Massague et al.
FEBS LETTERS (2006)
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
EM Shore et al.
NATURE GENETICS (2006)
Erk1/2 signaling is required for Tgf-β2-induced suture closure
LA Opperman et al.
DEVELOPMENTAL DYNAMICS (2006)
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
JP Habashi et al.
SCIENCE (2006)
Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
AM Valdes et al.
ARTHRITIS AND RHEUMATISM (2006)
Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFβ receptor (Tgfbr2) mutant mice
B Choudhary et al.
DEVELOPMENTAL BIOLOGY (2006)
Thrombospondin 1 mediates angiotensin II induction of TGF-β activation by cardiac and renal cells under both high and low glucose conditions
Y Zhou et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment
K Janssens et al.
JOURNAL OF MEDICAL GENETICS (2006)
BMP signaling in the cartilage growth plate
Robert Pogue et al.
CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 76 (2006)
Losartan attenuates bleomycin-induced pulmonary fibrosis in rats
HW Yao et al.
RESPIRATION (2006)
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development
T Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
LG Raisz
JOURNAL OF CLINICAL INVESTIGATION (2005)
Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossification
E Minina et al.
GENE EXPRESSION PATTERNS (2005)
Bone mineral density in sclerosteosis;: Affected individuals and gene carriers
JC Gardner et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Neutralization of transforming growth factor-β attenuates hypertension and prevents renal injury in uremic rats
P Lavoie et al.
JOURNAL OF HYPERTENSION (2005)
Visualization of spatiotemporal activation of Notch signaling: Live monitoring and significance in neural development
J Kohyama et al.
DEVELOPMENTAL BIOLOGY (2005)
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2
P Seemann et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
GG Loots et al.
GENOME RESEARCH (2005)
Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA
LS de la Peña et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2005)
Wnt signaling inhibits adipogenesis through β-catenin-dependent and -independent mechanisms
JA Kennell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A single residue of GDF-5 defines binding specificity to BMP receptor IB
J Nickel et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Bone Morphogenetic Protein signaling in joint homeostasis and disease
RJU Lories et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2005)
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-β-independent mechanism
J Rodríguez-Vita et al.
CIRCULATION (2005)
Canonical Wnt/β-catenin signaling prevents osteoblasts from differentiating into chondrocytes
TP Hill et al.
DEVELOPMENTAL CELL (2005)
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
DA Glass et al.
DEVELOPMENTAL CELL (2005)
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
BS Yoon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome
H Wurdak et al.
GENES & DEVELOPMENT (2005)
Distinct functions for Bmp signaling in lip and palate fusion in mice
W Liu et al.
DEVELOPMENT (2005)
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
BL Loeys et al.
NATURE GENETICS (2005)
Bone mass effects of a BMP4 gene polymorphism in postmenopausal women
LR Babu et al.
BONE (2005)
Overexpression of Smad2 in Tgf-β3-null mutant mice rescues cleft palate
XM Cui et al.
DEVELOPMENTAL BIOLOGY (2005)
Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice
YH Hu et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Multiple effects of GDF-5 deficiency on skeletal tissues: Implications for therapeutic bioengineering
B Mikic
ANNALS OF BIOMEDICAL ENGINEERING (2004)
Heterotopic ossification
FS Kaplan et al.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2004)
Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1
GC Schwabe et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2004)
Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK:: a mechanism for activation of latent TGF-β1
T Naito et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells
M Dudas et al.
MECHANISMS OF DEVELOPMENT (2004)
αvβ3 Integrin interacts with the transforming growth factor β (TGFβ) type II receptor to potentiate the proliferative effects of TGFβ1 in living human lung fibroblasts
AK Scaffidi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Association study of candidate genes for the prevalence and progression of knee osteoarthritis
AM Valdes et al.
ARTHRITIS AND RHEUMATISM (2004)
Heterozygous TGFBR2 mutations in Marfan syndrome
T Mizuguchi et al.
NATURE GENETICS (2004)
Unique and redundant roles of Smad3 in TGF-β-mediated regulation of long bone development in organ culture
J Alvarez et al.
DEVELOPMENTAL DYNAMICS (2004)
Conditional deletion of the TGF-β type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones
MO Baffi et al.
DEVELOPMENTAL BIOLOGY (2004)
Molecular regulation of vascular smooth muscle cell differentiation in development and disease
GK Owens et al.
PHYSIOLOGICAL REVIEWS (2004)
Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-β regulation of osteoclast differentiation
M Karst et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
BMP receptor signaling is required for postnatal maintenance of articular cartilage
RB Rountree et al.
PLOS BIOLOGY (2004)
Angel shaped phalangeal dysplasia, hip dysplasia, and positional teeth abnormalities are part of the brachydactyly C spectrum associated with CDMP-1 mutations
M Holder-Espinasse et al.
JOURNAL OF MEDICAL GENETICS (2004)
Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology
F Ramirez et al.
PHYSIOLOGICAL GENOMICS (2004)
Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins
K Miyazono et al.
ONCOGENE (2004)
Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia
M Horiki et al.
JOURNAL OF CELL BIOLOGY (2004)
Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation:: TGF-β delays hypertrophy and PGE2 inhibits terminal differentiation
XP Zhang et al.
BONE (2004)
Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France
G Lesca et al.
HUMAN MUTATION (2004)
Transforming growth factor-β-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogenactivated protein kinase and Wnt signaling cross-talk
R Tuli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2
K Lehmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Smad-dependent and Smad-independent pathways in TGF-β family signalling
R Derynck et al.
NATURE (2003)
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFP/ALK5 signaling
MJ Goumans et al.
MOLECULAR CELL (2003)
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
DH Zhang et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Smad6 is induced by BMP-2 and modulates chondrocyte differentiation
XF Li et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2003)
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
Y Mori-Akiyama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Genetic regulation of osteoclast development and function
SL Teitelbaum et al.
NATURE REVIEWS GENETICS (2003)
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1β-stimulated matrix metalloproteinase-13 expression in human chondrocytes
HJ Im et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The oncoprotein ski acts as an antagonist of transforming growth factor-β signaling by suppressing Smad2 phosphorylation
C Prunier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A mutation affecting the latency-associated peptide of TGFβ1 in Camurati-Engelmann disease enhances osteoclast formation in vitro
NWA McGowan et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
MK Khokha et al.
NATURE GENETICS (2003)
High bone mass in mice expressing a mutant LRP5 gene
P Babij et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
S Ivkovic et al.
DEVELOPMENT (2003)
Developmental regulation of the growth plate
HM Kronenberg
NATURE (2003)
Regression of renal vascular and glomerular fibrosis: Role of angiotensin II receptor antagonism and matrix metalloproteinases
JJ Boffa et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
The BMP antagonist noggin regulates cranial suture fusion
SM Warren et al.
NATURE (2003)
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
ER Neptune et al.
NATURE GENETICS (2003)
Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis
BL Langdahl et al.
BONE (2003)
Transforming growth factor-β1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein
K Janssens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bone matrix proteins: their function, regulation, and relationship to osteoporosis
MF Young
OSTEOPOROSIS INTERNATIONAL (2003)
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
DG Winkler et al.
EMBO JOURNAL (2003)
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Y Ito et al.
DEVELOPMENT (2003)
Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal
JE Wergedal et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Linkage of osteoporosis to chromosome 20p12 and association to BMP2
U Styrkarsdottir et al.
PLOS BIOLOGY (2003)
Tgfβ2-/-Tgfβ3-/- double knockout mice display severe midline fusion defects and early embryonic lethality
N Dünker et al.
ANATOMY AND EMBRYOLOGY (2002)
Age-related changes in cartilage endogenous osteogenic protein-1 (OP-1)
S Chubinskaya et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
H Akiyama et al.
GENES & DEVELOPMENT (2002)
The mutational spectrum of brachydactyly type C
DB Everman et al.
AMERICAN JOURNAL OF MEDICAL GENETICS (2002)
Effect of transforming growth factor-β1, insulin-like growth factor-1, and hepatocyte growth factor on proteoglycan production and regulation in canine melanoma cell lines
M Serra et al.
AMERICAN JOURNAL OF VETERINARY RESEARCH (2002)
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population
K Staehling-Hampton et al.
AMERICAN JOURNAL OF MEDICAL GENETICS (2002)
Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome)
M Faiyaz-Ul-Haque et al.
CLINICAL GENETICS (2002)
High bone density due to a mutation in LDL-receptor-related protein 5
LM Boyden et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis
N Tsumaki et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2002)
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1
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JOURNAL OF CELL BIOLOGY (2002)
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
W Balemans et al.
JOURNAL OF MEDICAL GENETICS (2002)
Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia
EM Shore et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
RD Little et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta 1 (TGF-beta 1) and its signaling pathway
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JOURNAL OF HUMAN GENETICS (2002)
Contribution of adventitial fibroblasts to neointima formation and vascular remodeling - From innocent bystander to active participant
S Sartore et al.
CIRCULATION RESEARCH (2001)
Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome
T Takahashi et al.
CLINICAL GENETICS (2001)
Adhesion receptors of vascular smooth muscle cells and their functions
EP Moiseeva
CARDIOVASCULAR RESEARCH (2001)
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
YQ Gong et al.
CELL (2001)
Transforming growth factor β affects osteoclast differentiation via direct and indirect actions
JMW Quinn et al.
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Human disease-causing NOG missense mutations:: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding
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Regulation of limb patterning by extracellular microfibrils
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JOURNAL OF CELL BIOLOGY (2001)
Transforming growth factor-β induces osteoclast ruffling and chemotaxis:: Potential role in osteoclast recruitment
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JOURNAL OF BONE AND MINERAL RESEARCH (2001)
The perichondrium plays an important role in mediating the effects of TGF-β1 on endochondral bone formation
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DEVELOPMENTAL DYNAMICS (2001)
TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
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EMBO JOURNAL (2001)
Domain-specific mutations of a transforming growth factor (TGF)-β1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-β1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
X Yang et al.
JOURNAL OF CELL BIOLOGY (2001)
Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
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EMBO JOURNAL (2001)
Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression
M Wan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
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AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
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HUMAN MOLECULAR GENETICS (2001)
New developments in cranial suture research
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PLASTIC AND RECONSTRUCTIVE SURGERY (2001)
Progressive osseous heteroplasia
FS Kaplan et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2000)
Endogenous production of TGF-β is essential for osteoclastogenesis induced by a combination of receptor activator of NF-κB ligand and macrophage-colony-stimulating factor
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JOURNAL OF IMMUNOLOGY (2000)
Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts
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BMP type II receptor is required for gastrulation and early development of mouse embryos
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BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
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Angiotensin II upregulates transforming growth factor-β type I receptor on rat vascular smooth muscle cells
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Effect of transforming growth factor beta 1 on chondrogenic differentiation of cultured equine mesenchymal stem cells
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AMERICAN JOURNAL OF VETERINARY RESEARCH (2000)
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