Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 10, Issue 5, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a022202
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Funding
- National Institutes of Health (NIH) [1F31DE024693-01, 1K08GM109105-01, P01 HD70394, R01 DE020843]
- NIH/NCRR [S10RR026475-01]
- Michael Geisman Fellowship from Osteogenesis Imperfecta Foundation
- Plastic Surgery Foundation National Endowment Award
- International FOP Association
- Baylor College of Medicine Intellectual and Developmental Disabilities Research Center [HD024064]
- Rolanette and Berdon Lawrence Bone Disease Program of Texas
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Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-beta (TGF-(beta) family. This review focuses on the roles of TGF-beta family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes. We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-beta family signaling can drive human disease by affecting mesenchymal differentiation.
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