Journal
GASTROENTEROLOGY RESEARCH AND PRACTICE
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/6265150
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Funding
- National Science Foundation Research Scholarship [NSF/SCH/2015/04]
- University of Sri Jayewardenepura Research [ASP/01/RE/MED/2017/28]
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Background. The pro-and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-alpha) in H. pylori-infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results. The expression levels of IL-17 and IL-23 were significantly higher in H. pylori-infected patients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion. The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population.
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