Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1859, Issue 9, Pages 1725-1739Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2017.03.015
Keywords
ARDS; NRDS; Meconium aspiration sindrome; Exogenous surfactant therapy; Air-liquid interface; Respiratory mechanics
Categories
Funding
- Spanish Ministry of Economy and Competitiveness [BIO2015-67930-R]
- Regional Government of Madrid [S2013/MIT-2807]
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Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There, surfactant forms interfacial films at the air water interface, reducing dramatically surface tension and thus stabilizing the air-exposed interface to prevent alveolar collapse along respiratory mechanics. The absence or deficiency of surfactant produces severe lung pathologies. This review describes some of the most important surfactant-related pathologies, which are a cause of high morbidity and mortality in neonates and adults. The review also updates current therapeutic approaches pursuing restoration of surfactant operative films in diseased lungs, mainly through supplementation with exogenous clinical surfactant preparations. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escriba. (C) 2017 Elsevier B.V. All rights reserved.
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