Journal
ALZHEIMERS & DEMENTIA
Volume 11, Issue 1, Pages 70-98Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.04.514
Keywords
Sensory; Motor; Olfaction; Vision; Auditory function; Alzheimer's disease; Aging
Categories
Funding
- NIA NIH HHS [R01 AG044920, P30 AG010124, RF1 AG015819, P50 AG005146, R01 AG041795, R01 AG017917, R01 AG037693, P30 AG008017, P50 AG005134, R01 AG004085, R01 AG015819, R01 AG019714, R01 AG031278, P30 AG062421, R01 AG038791] Funding Source: Medline
- NIDCD NIH HHS [K23 DC011279, R01 DC008983] Funding Source: Medline
- NIH HHS [DP2 OD006662] Funding Source: Medline
- NINDS NIH HHS [R21 NS085711] Funding Source: Medline
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Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled Sensory and Motor Dysfunctions in Aging and AD. The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links. among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting. amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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