Journal
AGEING RESEARCH REVIEWS
Volume 38, Issue -, Pages 40-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2017.07.002
Keywords
Dendritic cells; Inhibitory molecules; Aging; Cancer
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Funding
- School of Biomedical Sciences, Curtin University
- Cancer Council Western Australia
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Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients. (C) 2017 Elsevier B.V. All rights reserved.
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