Journal
ACS NANO
Volume 11, Issue 9, Pages 9330-9339Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b04731
Keywords
biofilm; gold nanoparticles; mixed charged zwitterion; pH-responsive; photothermal therapy
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Funding
- National Natural Science Foundation of China [21574114, 51573160]
- Science and Technology Planning Project of Zhejiang Province [2016C04002, 2016C54003]
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Biofilms that contribute to the persistent bacterial infections pose serious threats to global public health, mainly due to their resistance to antibiotics penetration and escaping innate immune attacks by phagocytes. Here, we report a kind of surface-adaptive gold nanoparticles (AuNPs) exhibiting (1) a self-adaptive target to the acidic microenvironment of biofihn, (2) an enhanced photothermal ablation of methicillin-resistant Staphylococcus aureus (MRSA) biofilm under near-infrared (NIR) light irradiation, NIR AuNPs Injection NIR Irradiation and (3) no damage to the healthy tissues around the biofilm. Originally, AuNPs were readily prepared by surface modification with pH-responsive mixed charged zwitterionic self-assembled monolayers consisting of weak electrolytic 11-mercaptoundecanoic acid (HS-C10-COOH) and strong electrolytic (10-mercaptodecyl)trimethylammonium bromide (HS-C-30-N-4). The mixed charged zwitterion-modified AuNPs showed fast pH-responsive transition from negative charge to positive charge, which enabled the AuNPs to disperse well in healthy tissues (pH similar to 7.4), while quickly presenting strong adherence to negatively charged bacteria surfaces in MRSA biofilm (pH similar to 5.5). Simultaneous AuNP aggregation within the MRSA biofilm enhanced the photothermal ablation of MRSA biofilm under NIR light irradiation. The surrounding healthy tissues showed no damage because the dispersed AuNPs had no photothermal effect under NIR light. In view of the above advantages as well as the straightforward preparation, AuNPs developed in this work may find potential applications as a useful antibacterial agent in the areas of healthcare.
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