Journal
JOURNAL OF FUNGI
Volume 3, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jof3030035
Keywords
Cryptococcus; innate immune response; fungal recognition; host-fungus interactions
Categories
Funding
- National Institutes of Health (NIH) [K08 AI130366]
- Stony Wold-Herbert Fund Fellowship
- Dana Foundation as a Memorial Sloan Kettering Cancer Center Clinical Scholar in Biomedical Research
- NIH/National Cancer Institute (NCI) Cancer Center Support Grant [P30 CA008748]
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Cryptococcus species are encapsulated fungi found in the environment that predominantly cause disease in immunocompromised hosts after inhalation into the lungs. Even with contemporary antifungal regimens, patients with cryptococcosis continue to have high morbidity and mortality rates. The development of more effective therapies may depend on our understanding of the cellular and molecular mechanisms by which the host promotes sterilizing immunity against the fungus. This review will highlight our current knowledge of how Cryptococcus, primarily the species C. neoformans, is sensed by the mammalian host and how subsequent signaling pathways direct the anti-cryptococcal response by effector cells of the innate immune system.
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