Journal
AGEING RESEARCH REVIEWS
Volume 38, Issue -, Pages 18-27Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2017.07.001
Keywords
AMP-activated protein kinase; Fibrosis; Fibrogenesis; Aging; Inflammation; Excessive extracellular matrix
Categories
Funding
- National Natural Science Foundation of China [81500263, 81600306]
- China Postdoctoral Science Foundation [2016T90973, 2015M572681]
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Fibrosis is a common process characterized by excessive extracellular matrix (ECM) accumulation after inflammatory injury, which is also a crucial cause of aging. The process of fibrosis is involved in the pathogenesis of most diseases of the heart, liver, kidney, lung, and other organs/tissues. However, there are no effective therapies for this pathological alteration. Annually, fibrosis represents a huge financial burden for the USA and the world. 5'-AMP-activated protein kinase (AMPK) is a pivotal energy sensor that alleviates or delays the process of fibrogenesis. In this review, we first present basic background information on AMPK and fibrogenesis and describe the protective roles of AMPK in three fibrogenic phases. Second, we analyze the protective action of AMPK during fibrosis in myocardial, hepatic, renal, pulmonary, and other organs/tissues. Third, we present a comprehensive discussion of AMPK during fibrosis and draw a conclusion. This review highlights recent advances, vital for basic research and clinical drug design, in the regulation of AMPK during fibrosis. (C) 2017 Elsevier B.V. All rights reserved.
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