Journal
EUROPEAN EATING DISORDERS REVIEW
Volume 25, Issue 5, Pages 423-427Publisher
WILEY
DOI: 10.1002/erv.2524
Keywords
anorexia nervosa; intestinal microbiota; gut-brain-microbiota axis; clinical refeeding
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Funding
- Foundation of Hope
- UNC Center of Excellence for Eating Disorders Board of Visitors Fund
- TJ's Fund for Eating Disorders Research (Academy for Eating Disorders)
- CGIBD pilot feasibility grant [P30DK03498]
- Swedish Research Council (VR) [538-2013-8864]
- [K01 DK 092330]
- [R01 MH 105684]
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Anorexia nervosa, a severe psychiatric illness, is associated with an intestinal microbial dysbiosis. Individual microbial signatures dominate in healthy samples, even over time and under controlled conditions, but whether microbial markers of the disorder overcome inter-individual variation during the acute stage of illness or renourishment is unknown. We characterized daily changes in the intestinal microbiota in three acutely ill patients with anorexia nervosa over the entire course of hospital-based renourishment and found significant, patient-specific changes in microbial composition and diversity. This preliminary case series suggests that even in a state of pathology, individual microbial signatures persist in accounting for the majority of intestinal microbial variation. Copyright (C) 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
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