Journal
GELS
Volume 3, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/gels3030029
Keywords
peptides; D-amino acids; chirality; hydrogels; drugs; release; self-assembly; co-assembly; naproxen; ketoprofen
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Funding
- Italian Ministry of University and Research (MIUR) through the Scientific Independence of young Researchers (SIR) program (HOT-SPOT project) [RBSI14A7PL]
- Ramon Areces Foundation
- European Social Fund Operational Programme 2014-2020 (Axis 3-Education and Training, Specific Programmen. 26-TALENTS3-Slavko Kralj's fellowship)
- Beneficentia Stiftung Fundation
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Supramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards sustained release over time, which could be achieved given that the drug participates in the hydrogel nanostructure, and it is not simply physically entrapped within the gel matrix. (D)Leu-Phe-Phe is an attractive building block of biomaterials in light of the peptide's inherent biocompatibility and biodegradability. This study evaluates the assembly of the tripeptide in the presence of either of the anti-inflammatory drugs ketoprofen or naproxen at levels analogous to commercial gel formulations. Fourier-transformed infrared (FT-IR), circular dichroism, Thioflavin T fluorescence, transmission electron microscopy (TEM), and oscillatory rheometry are used. Drug release over time is monitored by means of reverse-phase high performance liquid chromatography, and shows different kinetics for the two drugs.
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