Journal
EUROPEAN RESPIRATORY REVIEW
Volume 26, Issue 144, Pages -Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/16000617.0018-2017
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Funding
- Medical Research Council UK [G1002610]
- Alpha 1 Foundation, British Lung Foundation and Papworth Hospital NHS Foundation Trust
- MRC [G1002610, G0601840] Funding Source: UKRI
- Medical Research Council [G1002610, G0601840] Funding Source: researchfish
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Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.
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