Journal
BIOMEDICAL MICRODEVICES
Volume 19, Issue 3, Pages -Publisher
SPRINGER
DOI: 10.1007/s10544-017-0207-y
Keywords
Porous microneedle; Electrolyte permeable; Edema; Transdermalmonitoring
Funding
- Center of Innovation Program (COI) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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An array of porous microneedles was developed for minimally-invasive transdermal electrolytic connection through the human skin barrier, the stratum corneum. The length of microneedle was designed to be 100 mu m so that it penetrates into the epidermis layer without pain. Each microneedle was supported by a thicker cylindrical post protruding from a planar substrate to realize its effective penetration even into elastic human skin. Since this support (post and substrate) was equally porous as the needles, the needle chip was entirely permeable for electrolyte. This ion-conductive porous microneedle array was applied to the transdermal conductometry with small direct current for local monitoring of intercellular swelling, edema. The porous needle-based electrode system could be a platform for various transdermal electrical diagnosis and treatments.
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