Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 32, Issue 6, Pages 353-359Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317517709549
Keywords
Alzheimer's disease; dementia; oxidative stress markers; metallic ions
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Funding
- Science and Technology Planning Project of Jiaxing [2014AY21066]
- Key Subject funds of Tongxiang [201402054]
- Open Project from Zhejiang Key Laboratory of Mental Disorder Diagnosis and Prevention Technology
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We investigated oxidative stress markers and metal ions in patients with Alzheimer's disease (AD). The serum levels of ceruloplasmin (CER), C-reactive protein (CRP), uric acid (UA), homocysteine (Hcy), copper, iron, and zinc were determined in 125 patients with AD (mild, n = 2 8; moderate, n = 42; and severe, n = 55) and 40 healthy control (HC) participants. Compared to HC, CER and UA levels were significantly lower in moderate and severe AD groups, whereas CRP and Hcy levels were significantly higher in the severe AD group. Copper level was significantly higher in moderate and severe AD groups than the other groups. Compared to HC, iron level was significantly higher in patients with AD, whereas zinc level was significantly lower in patients with AD. In patients with AD, the severity of cognitive impairment was positively correlated with CER, UA, and zinc levels, whereas it was negatively correlated with copper level. Taken together, our findings provide a novel approach to assess AD progression.
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