Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1863, Issue 9, Pages 2282-2292Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2017.06.018
Keywords
Endometriosis; Endometrium; Microarray; MicroRNA; Stroma; Tissue heterogeneity
Funding
- Estonian Ministry of Education and Research [IUT34-16]
- Enterprise Estonia [EU48695]
- EU FP7-PEOPLE-IAPP grant SARM [324509]
- European Commission Horizon research and innovation programme [692065, 691058]
- Marie Curie Actions (MSCA) [691058] Funding Source: Marie Curie Actions (MSCA)
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In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large number of dysregulated miRNAs have been reported. However, the concordance between the result of different studies has remained small. One potential explanation for limited overlap between the proposed disease-related miRNAs could be the heterogeneity in tissue composition, as some studies have compared highly heterogeneous whole-lesion biopsies with endometrial tissue, some have compared the endometrium from patients and controls, and some have used pure cell fractions isolated from lesions and endometrium. This review focuses on the results of published miRNA studies in endometriosis to reveal the potential impact of tissue heterogeneity on the discovery of disease-specific miRNA alterations in endometriosis. Additionally, functional studies that explore the roles of endometriosis-involved miRNAs are discussed.
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