Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 36, Issue -, Pages 262-273Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.07.020
Keywords
Cyclocarya paliurus; Polysaccharides; Chemical composition; Lipid-lowering effect; Insulin resistance; Lipid metabolism-related enzymes
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Funding
- National Natural Science Foundation of China [31560459, 31160319]
- Natural Science Foundation of Jiangxi Province, China [20151BAB204037]
- Science Funds of Educational Commission of Jiangxi Province, China [KJLD13027, GJJ13281]
- Graduate Innovative Special Fund Projects of Jiangxi Province, China [YC2015-S176]
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The present study was performed to analyse the chemical composition of Cyclocarya paliurus polysaccharides (CPP) and investigate their lipid-lowering effects on high-fat diet (HFD)-induced hyperlipidaemic rats. CPP mainly consisted of two polysaccharides with an average molecular weight (M-w) of 190.1 and 2.1 kDa, as well as 67.8% total sugar, 19.23% uronic acid, 6.56% proteins, and six monosaccharides. CPP treatment markedly reduced the plasma glucose level, restored lipid profile changes, modulated the activities of hepatic lipid-related enzymes, suppressed hypertrophy of visceral adipose tissue (VAT), and improved hepatic steatosis. In addition, CPP ameliorated glucose tolerance and insulin resistance, which could be attributed to the regulation of CCAAT/enhancer binding protein-alpha (C/EBP alpha), peroxisome proliferator-activated receptor (PPAR)-gamma, PPAR delta, and c-CbI-associated protein (CAP) expression. The present findings suggest that CPP exhibit a lipid-lowering effect by regulating the activities of hepatic lipid metabolism-related enzymes and alleviating insulin resistance. (C) 2017 Elsevier Ltd. All rights reserved.
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