Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 95, Issue 9, Pages 917-926Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjc-2017-0203
Keywords
nanoparticles; in vivo toxicity; toxicology; experimental procedures
Categories
Funding
- Spanish Ministerio de Economia y Competitividad (MINECO) [BFU2014-59009-P]
- CYTED [214RT0482]
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Toxicological tests of a xenobiotic play a key role to determine the safety of the new compound before it reaches the market. In this review article, we describe the main types of toxicological studies that can be performed in vivo to detect a possible undesired effect of a xenobiotic with especial emphasis on the data available for the different types of nanoparticles. The different procedures described in this review allow to obtain valuable information about the possible toxic effects of a xenobiotic to minimize the possible risks for patients once the compound has been approved for therapeutic use.
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