Journal
CLINICS IN CHEST MEDICINE
Volume 38, Issue 3, Pages 451-464Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2017.04.007
Keywords
Cryptococcus; Cryptococcosis; Fungal lung infection; Endemic mycoses; Treatment
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Cryptococcus is among the most common invasive fungal pathogens globally and is one of the leading causes of acquired immunodeficiency virus-related deaths. Cryptococcus neoformans and Cryptococcus gattii are the most clinically relevant species and account for most cryptococcal disease. Pulmonary manifestations can range from mild symptoms to life-threatening infection. Treatment is tailored based on the severity of pulmonary infection, the presence of disseminated or central nervous system disease, and patient immune status. Amphotericin B and flucytosine followed by fluconazole remain the standard agents for the treatment of severe cryptococcal infection.
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