Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 36, Issue -, Pages 195-202Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.07.009
Keywords
Energy expenditure; UCP1; Obesity; Type 2 diabetes; WAT; BAT; GLUT4
Categories
Funding
- Grants-in-Aid for Scientific Research [15H04545] Funding Source: KAKEN
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Interest in a novel biological agent fucoxanthin (Fx) has been growing in recent years, which connects Fx to increases in energy expenditure and has implications for the management of obesity and type 2 diabetes mellitus (T2DM). Several molecular targets offer the most hope for influencing energy expenditure. One of the keys for success will be uncoupling protein 1 (UCP1). Fx can reduce the excess fat accumulation in abdominal white adipose tissue (WAT), which is primarily based on the up-regulation of the thermogenesis through UCP1 expression in both brown adipose tissue (BAT) and abdominal WAT. Fx down regulates the expression of pro-inflammatory adipokines involved in insulin resistance from abdominal WAT and subsequently normalizes the blood glucose level. In addition, Fx can promote glucose utilization in skeletal muscle by up-regulating glucose transporter 4 (GLUT4) expression and promoting its translocation to the cell membrane from the cytosol. (C) 2017 Elsevier Ltd. All rights reserved.
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