Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 32, Issue -, Pages 160-169Publisher
ELSEVIER
DOI: 10.1016/j.jff.2017.02.022
Keywords
R. idaeus rhizomes; Lignans; Antioxidant activity; Neuroprotective effect; Quantification
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Funding
- Key Laboratory of Structure Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education
- National Natural Science Foundation of Liaoning Province [2015020738, L2015518, L2015519]
- Foundation from the Project of Innovation Team [LT2015027]
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Rubus idaeus L. is caneberries from the genus Rubus that have been cultivated as food and herbal medicine, and is known to demonstrate strong antioxidant capability. In the present study, five new lignans, along with 13 known compounds, were isolated from ethanol extracts of R. idaeus rhizomes. An HPLC-MS/MS method was established and successfully applied to quantification of 14 compounds from leaves (LR), fruits (FR) and rhizomes (RR) of R. idaeus. All the compounds showed in vitro antioxidant activities, and three lignans revealed in vitro neuroprotective protective effects against H2O2-induced neurodegeneration in SH-SY5Y cells, the crude RR, LR and FR were found to have both in vitro antioxidant activities and neuroprotective effects. (C) 2017 Elsevier Ltd. All rights reserved.
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