Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 38, Issue -, Pages 168-179Publisher
ELSEVIER
DOI: 10.1016/j.jff.2017.09.013
Keywords
Silybum marianum; Silychristin A; Diabetes; alpha-Glucosidase; Streptozotocin; Pancreatic islet beta cells
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Funding
- Doctoral Starting-up Foundation of Liaoning Science and Technology Department [51120390]
- Foundation of Liaoning Education Committee [51120427]
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In the present study, the hypoglycemic effect of silychristin A on streptozotocin (STZ)-induced type 1 diabetes in rats was evaluated and the underlying pharmacological mechanism was further elucidated in vitro. Silychristin A significantly lowered the glucose level, increased insulin secretion, and improved the structure of beta cells in STZ-induced rats. Accordantly, reactive oxygen species (ROS) production induced by STZ or high concentration of glucose (HG) was effectively suppressed by silychristin A in pancreatic INS-1 beta cells evaluated by flow cytometry. Western blot analysis demonstrated that silychristin A markedly suppressed STZ or HG induced cell apoptosis. In addition, in vitro inhibitory effect of silychristin A on a-glucosidase and molecular docking analysis revealed that silychristin A could reduce the digestion rate of carbohydrates. These findings indicate that silychristin A may be useful as a potential functional food ingredient against oxidative stress-mediated destruction of pancreatic islet cells and inhibition of alpha-glucosidase activity. (C) 2017 Elsevier Ltd. All rights reserved.
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