Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 9, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00694-17
Keywords
16S rRNA methylase; Pseudomonas aeruginosa; carbapenemase; multidrug resistance
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Funding
- International Health Cooperation Research [29-S-5]
- Okinawa Communicable Disease Research Hub Formation Promotion Project
- Okinawa Prefectural Government Commissioned Projects
- Japan Agency for Medical Research and Development (AMED)
- JSPS KAKENHI [16K19133]
- Grants-in-Aid for Scientific Research [16K19133] Funding Source: KAKEN
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A total of 11 multidrug-resistant Pseudomonas aeruginosa clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1, and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with the same gene in RmtF. To our knowledge, this is the first report describing carbapenemase-and 16S rRNA methyltransferase-coproducing P. aeruginosa clinical isolates in Nepal.
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