Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 33, Issue -, Pages 176-180Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.03.036
Keywords
Casein hydrolysate; Faecal mucin; Rat intestine; Gene expression; O-linked glycoprotein
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Funding
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO) [ALIBIRDCM P2013/ABI-2728, AGL2015-66886-R]
- MINECO
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The aim of the present study was to investigate the in vivo effect on rat intestinal mucus production of a casein hydrolysate that had been previously shown a mucin stimulatory effect in human goblet cells (HT29-MTX). A significant rise of O-linked glycoproteins in faeces after 2 and 8 weeks of the casein hydrolysate intake was observed. In agreement with this increased secretion, the relative expression for the genes that encode the secreted MUC2 and the membrane-bound MUC3 was significantly increased in ileum and colon. Mucus material in the small intestine lumen of rats fed the casein hydrolysate was higher than that found in control rats, however the change did not reach statistical difference. This study confirms in vivo the potential effect on mucus gastrointestinal protection of this casein hydrolysate. (C) 2017 Elsevier Ltd. All rights reserved.
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