Journal
ANNALS OF THORACIC SURGERY
Volume 104, Issue 3, Pages 751-759Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2017.02.052
Keywords
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Funding
- Knoebel Institute for Healthy Aging [89546-142235]
- University of Denver [89610-142235]
- University of Denver Postdoctoral Fellowship Award
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Background. Leaflet thrombosis after valve-in-valve (ViV) procedure has been increasingly recognized. This study aimed to investigate the flow dynamics aspect of leaflet thrombosis by quantifying the blood stasis on the noncoronary and coronary leaflets of a surgical aortic valve (SAV) and a transcatheter aortic valve (TAV) in a ViV setting. Methods. Two computational models, representing a SAV and a TAV in ViV setting, were developed in a patient-specific geometry. Three-dimensional flow fields were obtained through a fluid-solid interaction modeling approach to study the difference in blood residence time (BRT) on the coronary and noncoronary leaflets. Results. Longer BRT was observed on the TAV leaflets compared with the SAV, specifically near the leaflet fixed boundary. Particularly, at the end of diastole, the areas of high BRT (>= 1.2 seconds) on the surface of the TAV model model. The distribution of BRT on the three leaflets exhibited a similar pattern in the model for the TAV in ViV setting. That was in contrast to the SAV model where large areas of high BRT were observed on the noncoronary leaflet. Conclusions. Geometric confinement of the TAV by the leaflets and the frame of the degenerated bio-prosthesis that circumferentially surround the TAV stent increases the BRT on the leaflets, which may act as a permissive factor in the TAV leaflet thrombosis after ViV procedure. A similar distribution pattern of BRT observed on the TAV leaflets may explain the similar rate of occurrence of thrombosis on the three leaflets. (C) 2017 by The Society of Thoracic Surgeons
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