Journal
BIOSCIENCE TRENDS
Volume 11, Issue 3, Pages 363-365Publisher
IRCA-BSSA
DOI: 10.5582/bst.2017.01037
Keywords
Proteomic analysis; let-7f-5p; IGF2BP1; HeLa cells
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Funding
- National Natural Science Foundation of China [81560260]
- Inner Mongolia Natural Science Foundation of China [2014MS0346, 2015MS08125, 2016MS(LH)0813]
- MERCK CREAT Project
- Chinese Medical Association fund [16020260642]
- Doctorial Fund of Inner Mongolia Medical University Hospital
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MicroRNAs are a class of small, endogenous, non-coding RNAs mediating posttranscriptional gene silencing. The current authors hypothesized that let-7f-5p is likely involved in cell invasion and proliferation by regulating the expression of target genes. The current study combined let-7f-5p with iTRAQ to assess its effect on gene expression in HeLa cells. Results indicated that 164 proteins were expressed at different levels in HeLa cells overexpressing let-7f-5p and negative controls and that 172 proteins were expressed at different levels in let-7f-5p-silenced HeLa cells and negative controls. Results indicated that let-7f-5p may suppress insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) in HeLa cells.
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