Journal
BIOSCIENCE TRENDS
Volume 11, Issue 6, Pages 612-618Publisher
IRCA-BSSA
DOI: 10.5582/bst.2017.01259
Keywords
Yin-yang; cancer; gene; protein; cell
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Funding
- National Natural Science Foundation of China [31402237]
- Southwest University's Fund for Young Researchers (Rongchang Campus) [132030/20700950]
- Foundation to Support Doctors at Southwest University
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Great achievements have been made in human cancer research, but most of this research is focused on conditions at the microscopic rather than the systemic level. Recent studies have increasingly cited the ancient Chinese theory of yin-yang in an effort to expand beyond the microscopic level. Various cancer-associated genes and proteins such as mitogen-activated protein kinase (MAPK), p38, p53, c-Myc, tumor necrosis factor (TNF)-alpha, NF-kappa B, Cyclin D1, and cyclin-dependent kinase (CDK) and cells such as T cells, B cells, macrophages, neutrophils, and fibroblasts have been reported to regulate various types of cancers in a yin-yang manner. These studies have brought the theory of yin-yang into vogue in cancer research worldwide.
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