Journal
ONCOTARGETS AND THERAPY
Volume 10, Issue -, Pages 2349-2363Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S133385
Keywords
immune checkpoint blockade; programmed cell death 1; b7 antigens; hematological cancer; lymphoma; chronic lymphocytic leukemia
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Funding
- Romanian National Authority for Scientific Research and Innovation, CNCS - UEFISCDI [PN-II-RU-TE-2014-4-2074]
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The co-inhibitory receptor programmed cell death (PD)-1, expressed by immune effector cells, is credited with a protective role for normal tissue during immune responses, by limiting the extent of effector activation. Its presently known ligands, programmed death ligands (PD-Ls) 1 and 2, are expressed by a variety of cells including cancer cells, suggesting a role for these molecules as an immune evasion mechanism. Blocking of the PD-1-PD-L signaling axis has recently been shown to be effective and was clinically approved in relapsed/refractory tumors such as malignant melanoma and lung cancer, but also classical Hodgkin's lymphoma. A plethora of trials exploring PD-1 blockade in cancer are ongoing. Here, we review the role of PD-1 signaling in lymphoid malignancies, and the latest results of trials investigating PD-1 or PD-L1 blocking agents in this group of diseases. Early phase studies proved very promising, leading to the clinical approval of a PD-1 blocking agent in Hodgkin's lymphoma, and Phase III clinical studies are either planned or ongoing in most lymphoid malignancies.
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