Journal
ONCOTARGETS AND THERAPY
Volume 10, Issue -, Pages 1561-1573Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S126424
Keywords
immune evasion; mechanism; breast cancer; cytokines; apoptosis; PD-L1
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Funding
- National Natural Science Foundation of China [81372550]
- Program of Education Department of Liaoning Province [L2014307]
- Key Laboratory Programme of Education Department of Liaoning Province [LZ2015076, LZ2015080]
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Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body's immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail.
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