Journal
BIOCONJUGATE CHEMISTRY
Volume 28, Issue 9, Pages 2224-2229Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00312
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Funding
- National Natural Science Foundation of China (NSFC) [51573013]
- Deutsche Forschungsgemeinschaft (DFG) [WE 5837/1-1]
- National 1000 Young Talent Program
- KIT
- Deutsche Forschungsgemeinschaft (D.F.G.) [2039]
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Metal nanoclusters (NCs) hold great potential as novel luminescent nanomaterials in many applications, while the synthesis of highly luminescent metal NCs still remains challenging. In this work, we report self-assembling peptides as a novel bioinspired scaffold capable of significantly enhancing the luminescence efficiency of gold nanoclusters (AuNCs). The resulting AuNCs capped with motif-designed peptides can self-assemble to form nanofiber structures, in which the luminescence of AuNCs is enhanced nearly 70-fold, with 21.3% quantum yield. The underlying mechanism responsible for the luminescence enhancement has been thoroughly investigated by the combined use of different spectroscopic and microscopic techniques. The resultant highly luminescent AuNC-decorated peptide nanofibers exhibit physicochemical properties that are advantageous for biological applications. As a proof of concept, we demonstrate the use of these nanostructure as fluorescent thermometers and for imaging living cells, both showing very promising results.
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