Journal
ONCOTARGETS AND THERAPY
Volume 10, Issue -, Pages 879-884Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S128391
Keywords
C-reactive protein/albumin ratio; laryngeal squamous cell carcinoma; prognosis; survival
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Funding
- Sun Yat-sen University Clinical Research 5010 Program [2010008]
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Purpose: The present study was designed to retrospectively evaluate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC). Methods: One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 and October 2011 were retrospectively reviewed. Their serum CRP and ALB were quantified preoperatively. The relationship between the CRP/ALB ratio and the clinicopathologic features was analyzed. Receiver operating characteristic curve was used to calculate the prognostic value of the CRP/ALB ratio. Then, the Cox proportional hazards model was used in univariate and multivariate analyses to identify significant prognostic factors associated with disease-free survival and overall survival. Results: The cutoff value for CRP/ALB ratio was 0.047. An elevated CRP/ALB ratio was significantly associated with nodal metastasis, late disease stage, and recurrence. Also, high values of CRP/ALB ratio were significant predictors for poor overall survival and disease-free survival on multivariate analysis. Conclusion: Pretreatment CRP/ALB ratio may be a significant prognostic marker in LSCC.
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