Journal
JOURNAL OF MOLECULAR AND ENGINEERING MATERIALS
Volume 5, Issue 3, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S2251237317500113
Keywords
Stimuli-responsive; supramolecular hydrogel; self-healing; drug release; doxorubicin
Categories
Funding
- DST
- BRNS-DAE, India
- UGC
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An inexpensive, facile, and environmentally benign method has been developed for the preparation of stimuli-responsive and self-healing polyacrylic acid-chitosan-based supramolecular hydrogels. Guanidine hydrochloride is used as the supramolecular crosslinker to form an interconnected network with polyacrylic acid-chitosan complex. Because of the dynamic equilibrium between the hydrogen-bonding sites of the components, the hydrogels were found to be self-healable and sensitive to biochemical-stimulus, such as pH. Controlled loading of drug like doxorubicin and its significant anticancer activity of such hydrogels is worth mentioning.
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