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Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF
Paul T. Schumacker
CANCER CELL (2011)
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
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HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Julie Mathieu et al.
CANCER RESEARCH (2011)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
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Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α in Advanced Solid Tumors
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CLINICAL CANCER RESEARCH (2011)
Angiogenesis and molecular markers in advanced epithelial ovarian cancer: A retrospective study
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GYNECOLOGIC ONCOLOGY (2011)
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INVESTIGATIONAL NEW DRUGS (2011)
A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
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INVESTIGATIONAL NEW DRUGS (2011)
Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells
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INVESTIGATIONAL NEW DRUGS (2011)
Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101
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JOURNAL OF CONTROLLED RELEASE (2011)
Oxygen Sensing, Homeostasis, and Disease
David De Bels et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Nuclear Factor-κB-Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions
Zhuo-Xin Cheng et al.
PLOS ONE (2011)
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
Dimitrios Iliopoulos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
Yunqing Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
MECHANISMS OF DISEASE Oxygen Sensing, Homeostasis, and Disease
Gregg L. Semenza
NEW ENGLAND JOURNAL OF MEDICINE (2011)
LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1α via upregulation of VHL in a colon cancer cell line
Kyeong Lee et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Anti-HIF-1α antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy
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BIOMATERIALS (2010)
Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors
Kazuki Shimizu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Hypoxia inducible factors in cancer stem cells
J. M. Heddleston et al.
BRITISH JOURNAL OF CANCER (2010)
Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers
Satoshi Tsunetoh et al.
CANCER BIOLOGY & THERAPY (2010)
Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion
Erika Terzuoli et al.
CANCER RESEARCH (2010)
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
Sergio Rey et al.
CARDIOVASCULAR RESEARCH (2010)
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Norihiko Takeda et al.
GENES & DEVELOPMENT (2010)
Inhibition of Hypoxia Inducible Factor 1-Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
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MOLECULAR CELL (2010)
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
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ONCOGENE (2010)
A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The human HIF (hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction
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BIOCHEMICAL JOURNAL (2009)
Analysis of PTEN and HIF-1α and Correlation With Efficacy in Patients With Advanced Renal Cell Carcinoma Treated With Temsirolimus Versus Interferon-α
Robert A. Figlin et al.
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Hypoxia-Regulated Delta-like 1 Homologue Enhances Cancer Cell Stemness and Tumorigenicity
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Epithelial-Mesenchymal Transitions in Development and Disease
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CELL (2009)
Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer
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GASTROENTEROLOGY (2009)
HIF-1α and HIF-2α have divergent roles in colon cancer
Takaaki Imamura et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
The basics of epithelial-mesenchymal transition
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Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
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HIF-1 alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
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MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Gregory Bellot et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
被撤回的出版物: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (Retracted article. See vol. 119, 2022)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
KangAe Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cancer Stem Cells, Hypoxia and Metastasis
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SEMINARS IN RADIATION ONCOLOGY (2009)
Targeting phosphoinositide 3-kinase - Moving towards therapy
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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
The Angiopoietin-2 Gene of Endothelial Cells is Up-Regulated in Hypoxia by a HIF Binding Site Located in Its First Intron and by the Central Factors GATA-2 and Ets-1
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JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 alpha
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MOLECULAR CANCER THERAPEUTICS (2008)
A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
Lee M. Greenberger et al.
MOLECULAR CANCER THERAPEUTICS (2008)
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MOLECULAR CANCER THERAPEUTICS (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
NATURE CELL BIOLOGY (2008)
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
Huafeng Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
Benoit Vlaminck et al.
FEBS JOURNAL (2007)
Role of Wnt/β-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1α
Yong-Guang Jiang et al.
INTERNATIONAL JOURNAL OF UROLOGY (2007)
Detection and characterization of tumor hypoxia using pO2 histography
Peter Vaupel et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Hypoxia-inducible factors, stem cells, and cancer
Brian Keith et al.
CELL (2007)
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1α and mediates its destabilization in a VHL-independent manner
Daniela Fluegel et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors
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JOURNAL OF MEDICINAL CHEMISTRY (2007)
Vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy
Benjamin F. Johnson et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2007)
Over-expression of hypoxia-inducible factor-1α increases the invasive potency of LNCaP cells in vitro
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BJU INTERNATIONAL (2006)
Anthracyclines, small-molecule inhibitors of hypoxia-inducible factor-1 alpha activation
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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2006)
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-α expression but decrease functional transcriptional activity, DNA binding, and degradation
Dylan T. Jones et al.
CLINICAL CANCER RESEARCH (2006)
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α
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CANCER RESEARCH (2006)
Development of water-soluble metallofullerenes as X-ray contrast media
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EUROPEAN RADIOLOGY (2006)
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
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CANCER RESEARCH (2006)
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
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CANCER RESEARCH (2006)
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
DH Kong et al.
CANCER RESEARCH (2005)
Multi hydroxylated [Gd@C82(OH)22]n nanoparticles:: Antineoplastic activity of high efficiency and low toxicity
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NANO LETTERS (2005)
Hypoxia-induced dedifferentiation of tumor cells -: A mechanism behind heterogeneity and aggressiveness of solid tumors
H Axelson et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2005)
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradation
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CLINICAL CANCER RESEARCH (2004)
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
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NATURE MEDICINE (2004)
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
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CANCER CELL (2004)
Schedule-dependent inhibition of hypoxia-inducible factor-1α protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
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CANCER RESEARCH (2004)
Hypoxia-induced dedifferentiation in neuroblastoma cells
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CANCER LETTERS (2003)
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response
SA Dames et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
FIH-1:: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
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GENES & DEVELOPMENT (2001)
Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia
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