Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 46, Issue -, Pages 53-57Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2017.03.014
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Funding
- MEXT-JSPS [161102630, 24111004, 26460576]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [24111004, 16H02630, 17K15727] Funding Source: KAKEN
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The processing and presentation of major histocompatibility complex (MHC)-associated antigens depend on the intracellular digestion of self- and nonself-proteins, the loading of digested peptides onto MHC molecules, and the traffic of peptide MHC complexes to plasma membrane surface for display to interacting T cells. Recent studies have revealed unique machineries for antigen Processing and presentation in thymic antigen-presenting cells that display self-antigens to developing thymocytes for the formation of functionally competent yet self-tolerant T cell repertoire. Here, we briefly summarize those machineries, focusing on the biology of cortical and medullary thymic epithelial cells.
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