Journal
ACS NANO
Volume 11, Issue 9, Pages 8560-8578Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b04092
Keywords
cisplatin; CDDP; nanoparticles; drug delivery and release; hyperthermia; magnetic targeting; ultrasound; electro-motive force
Categories
Funding
- Engineering and Physical Sciences Research Council [EP/L026287/1, EP/L025825/1]
- EPSRC [EP/L025825/1, EP/L026287/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L025825/1, EP/L026287/1] Funding Source: researchfish
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Few chemotherapeutics have had such an impact on cancer management as cis-diamminedichloridoplatinum(II) (CDDP), also known as cisplatin. The first member of the platinum-based drug family, CDDP's potent toxicity in disrupting DNA replication has led to its widespread use in multidrug therapies, with particular benefit in patients with testicular cancers. However, CDDP also produces significant side effects that limit the maximum systemic dose. Various strategies have been developed to address this challenge including encapsulation within micro- or nanocarriers and the use of external stimuli such as ultrasound to promote uptake and release. The aim of this review is to look at these strategies and recent scientific and clinical developments.
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