Journal
NATURE IMMUNOLOGY
Volume 18, Issue 9, Pages 962-972Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3771
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Funding
- US National Institutes of Health [P50HG007735]
- Parker Institute for Cancer Immunotherapy
- Scleroderma Research Foundation
- Cancer Research Institute (Irvington Fellowship)
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Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and adaptive cell types. In this Review, we focus on mechanisms used by lncRNAs to regulate genes encoding products involved in the immune response, including direct interactions with chromatin, RNA and proteins. In addition, we address new areas of lncRNA biology, such as the functions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes. We emphasize critical gaps in knowledge and future prospects for the roles of lncRNAs in the immune system and autoimmune disease.
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