Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2017.00078
Keywords
neonatal; hypoxia-ischemia; encephalopathy; subplate; neurodevelopment; neuroserpin; neuroprotection
Categories
Funding
- Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford UK
- Clarendon Fund, Oxford, UK
- University College, University of Oxford, UK
- Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
- Medical Research Council [G00700311, G00900901]
- Academy of Medical Sciences Newton Advanced Fellowship
- Royal Society
- National Natural Science Foundation of China (UK/China) [NA160314/8161101585]
- MRC [MR/N026039/1] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [NAF005\\1003] Funding Source: researchfish
- Medical Research Council [MR/N026039/1] Funding Source: researchfish
Ask authors/readers for more resources
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidity throughout the adult population. Early preventative or neuroprotective interventions have the potential to rescue brain development in neonates, yet only one therapeutic intervention is currently licensed for use in developed countries. Recent investigations of the transient cortical layer known as subplate, especially regarding subplate's secretory role, opens up a novel set of potential molecular modulators of neonatal HI injury. This review examines the biological mechanisms of human neonatal HI, discusses evidence for the relevance of subplate-secreted molecules to this condition, and evaluates available animal models. Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post-ischaemic injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available