Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 37, Pages 11237-11241Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705471
Keywords
asymmetric hydrogenation; chiral alcohols; chiral pincer ligands; ketones; manganese
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Funding
- Leibniz Association [SAW-2016-LIKAT-1]
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A new chiral manganese PNP pincer complex is described. The asymmetric hydrogenation of several prochiral ketones with molecular hydrogen in the presence of this complex proceeds under mild conditions (30-40 degrees C, 4 h, 30 bar H-2). Besides high catalytic activity for aromatic substrates, aliphatic ketones are hydrogenated with remarkable selectivity (e.r. up to 92:8). DFT calculations support an outer sphere hydrogenation mechanism as well as the experimentally determined stereochemistry.
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