Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2017.00020
Keywords
HIF-1 alpha; hypoxia preconditioning; retina; neuroprotection; retinal degeneration
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Funding
- Fundamental Research Funds of the State Key Laboratory of Ophthalmology in Sun Yat-sen University
- National Basic Research Program (973 Program) of China [2015CB964600]
- National Natural Science Foundation of China [81670862, 81603200]
- New Jersey Health Foundation
- China Postdoctoral Science Foundation [2015M580758]
- Natural Science Foundation of Guangdong Province [2016A030310201]
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Hypoxia-inducible factor (HIF) is a transcription factor that facilitates cellular adaptation to hypoxia and ischemia. Long-standing evidence suggests that one isotype of HIF, HIF-1 alpha, is involved in the pathogenesis of various solid tumors and cardiac diseases. However, the role of HIF-1 alpha in retina remains poorly understood. HIF-1 alpha has been recognized as neuroprotective in cerebral ischemia in the past two decades. Additionally, an increasing number of studies has shown that HIF-1 alpha and its target genes contribute to retinal neuroprotection. This review will focus on recent advances in the studies of HIF-1 alpha and its target genes that contribute to retinal neuroprotection. A thorough understanding of the function of HIF-1 alpha and its target genes may lead to identification of novel therapeutic targets for treating degenerative retinal diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions.
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