4.6 Review

Therapeutic Role and Drug Delivery Potential of Neuroinflammation as a Target in Neurodegenerative Disorders

Journal

ACS CHEMICAL NEUROSCIENCE
Volume 8, Issue 8, Pages 1645-1655

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.7b00144

Keywords

Neuroinflammation; neuroinflammatory drugs; drug delivery

Funding

  1. Department of Science and Technology, Rajasthan [P.7(3)V.Pro./RD/2016/2724]

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Neuroinflammation, the condition associated with the hyperactivity of immune cells within the CNS (central nervous system), has recently been linked to a host range of neurodegenerative disorders. Targeting neuroinflammation could be of prime importance as recent research highlights the beneficial aspects associated with modulating the inflammatory mediators associated with the CNS. One of the main obstructions in neuroinflammatory treatments is the hindrance posed by the blood-brain barrier for the delivery of drugs. Hence, research has focused on novel modes of transport for drugs to cross the barrier through drug delivery and nanotechnology approaches. In this Review, we highlight the therapeutic advancement made in the field of neurodegenerative disorders by focusing on the effect neuroinflammation treatment has on these conditions.

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