Journal
FEMS MICROBIOLOGY REVIEWS
Volume 41, Issue -, Pages S49-S70Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fux035
Keywords
TNBS; DSS; infectious colitis; spontaneous colitis; adoptive cell transfer colitis; inflammatory bowel disease
Categories
Funding
- Agence Nationale de la Recherche [R12177BB]
- Danone Research
- European Research Council [ERC-2012-StG-20111109, ERC-2016-StG-715776]
- Region Midi-Pyrenees
- region Occitanie
- Alberta Health Innovates Solutions
- Agreenskills-INRA program (MICA department)
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Probiotics are defined as 'live microorganisms which when administered in adequate amounts confer a health benefit on the host'. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
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