Related references
Note: Only part of the references are listed.JNK at the crossroad of obesity, insulin resistance, and cell stress response
Giovanni Solinas et al.
MOLECULAR METABOLISM (2017)
Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor
Masaji Sakaguchi et al.
CELL METABOLISM (2017)
NF-κB and HIF crosstalk in immune responses
Laura D'Ignazio et al.
FEBS JOURNAL (2016)
Regulation of metabolism by the innate immune system
Denise E. Lackey et al.
NATURE REVIEWS ENDOCRINOLOGY (2016)
Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis
Vladimir Babaev et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function
Jeremie Boucher et al.
DIABETES (2016)
Adipose tissue macrophages: going off track during obesity
Lily Boutens et al.
DIABETOLOGIA (2016)
Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance
Kae Won Cho et al.
JOURNAL OF IMMUNOLOGY (2016)
New therapeutic approaches for the treatment of obesity
Alan R. Saltiel
SCIENCE TRANSLATIONAL MEDICINE (2016)
Signaling via the NFκB system
Simon Mitchell et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2016)
Molecular mechanisms of latent inflammation in metabolic syndrome. Possible role of sirtuins and peroxisome proliferator-activated receptor type γ
I. S. Stafeev et al.
BIOCHEMISTRY-MOSCOW (2015)
Genetics of Type 2 Diabetes-Pitfalls and Possibilities
Rashmi B. Prasad et al.
GENES (2015)
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Nathalie Esser et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2015)
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
Tracey McLaughlin et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
Targeting inflammation in the treatment of type 2 diabetes: time to start
Marc Y. Donath
NATURE REVIEWS DRUG DISCOVERY (2014)
OBESITY A complex role for adipose tissue macrophages
Shannon M. Reilly et al.
NATURE REVIEWS ENDOCRINOLOGY (2014)
Insulin Receptor Signaling in Normal and Insulin-Resistant States
Jeremie Boucher et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes
Elham Faghihimani et al.
ACTA DIABETOLOGICA (2013)
Salicylate (Salsalate) in Patients With Type 2 Diabetes A Randomized Trial
Allison B. Goldfine et al.
ANNALS OF INTERNAL MEDICINE (2013)
Molecular Basis of NF-kappa B Signaling
Johanna Napetschnig et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 42 (2013)
IKK interacts with rictor and regulates mTORC2
Yuanfei Xu et al.
CELLULAR SIGNALLING (2013)
Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial
J. Hensen et al.
DIABETES & METABOLISM (2013)
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease
Y. Imai et al.
DIABETES OBESITY & METABOLISM (2013)
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
A. B. Goldfine et al.
DIABETOLOGIA (2013)
An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
Shannon M. Reilly et al.
NATURE MEDICINE (2013)
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Myoung Sook Han et al.
SCIENCE (2013)
Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis
Justin I. Odegaard et al.
SCIENCE (2013)
The Role of the Immune System in Obesity and Insulin Resistance
Payal S. Patel et al.
JOURNAL OF OBESITY (2013)
Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance
Yoshinaga Kawano et al.
DIABETES (2012)
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
Adeline Bertola et al.
DIABETES (2012)
The insulin receptor substrate (IRS) proteins At the intersection of metabolism and cancer
Leslie M. Shaw
CELL CYCLE (2011)
Adipogenesis at a glance
Christopher E. Lowe et al.
JOURNAL OF CELL SCIENCE (2011)
TNF-alpha Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
Takara L. Stanley et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Signalling by insulin and IGF receptors: supporting acts and new players
Kenneth Siddle
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2011)
Crosstalk in NF-κB signaling pathways
Andrea Oeckinghaus et al.
NATURE IMMUNOLOGY (2011)
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Naoki Kumashiro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
Giovanni Solinas et al.
FASEB JOURNAL (2010)
Adipose tissue macrophages: their role in adipose tissue remodeling
Takayoshi Suganami et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2010)
Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
Sarah M. Choi et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Transcriptional factors that promote formation of white adipose tissue
Ursula A. White et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)
Lipid-induced insulin resistance: unravelling the mechanism
Varman T. Samuel et al.
LANCET (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Phosphorylation of IRS proteins, insulin action, and insulin resistance
Sigalit Boura-Halfon et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
beta-Arrestin1 interacts with the G-protein subunits beta(1)gamma(2) and promotes beta(1)gamma(2)-dependent Akt signalling for NF-kappa B activation
Ming Yang et al.
BIOCHEMICAL JOURNAL (2009)
The Protein Kinase IKKε Regulates Energy Balance in Obese Mice
Shian-Huey Chiang et al.
CELL (2009)
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Raymond B. Birge et al.
CELL COMMUNICATION AND SIGNALING (2009)
Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes
Claus M. Larsen et al.
DIABETES CARE (2009)
Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt
Dong Bai et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
The IRF family transcription factors in immunity and oncogenesis
Tomohiko Tamura et al.
ANNUAL REVIEW OF IMMUNOLOGY (2008)
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK
Han C. Dan et al.
GENES & DEVELOPMENT (2008)
Akt signaling: a damaging interaction makes good
Alex Toker
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Claus M. Larsen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Physiological roles of PKB/Akt isoforms in development and disease
B. Dummler et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
Carey N. Lumeng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Signalling through class I PI3Ks in mammalian cells
P. T. Hawkins et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Inflammation and insulin resistance
Steven E. Shoelson et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Myosin motor Myo1c and its receptor NEMO/IKK-γ promote TNF-α-induced serine307 phosphorylation of IRS-1
Yoshitaka Nakamori et al.
JOURNAL OF CELL BIOLOGY (2006)
Effects of etanercept in patients with the metabolic syndrome
LE Bernstein et al.
ARCHIVES OF INTERNAL MEDICINE (2006)
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
SP Weisberg et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
T Lawrence et al.
NATURE (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
DS Cai et al.
NATURE MEDICINE (2005)
IKK-β links inflammation to obesity-induced insulin resistance
MC Arkan et al.
NATURE MEDICINE (2005)
Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes
H Dominguez et al.
JOURNAL OF VASCULAR RESEARCH (2005)
PDK1, the master regulator of AGC kinase signal transduction
A Mora et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)
Cell type-specific expression of the IκB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-κB activation
JA Gustin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance
Y Zick
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
The two NF-κB activation pathways and their role in innate and adaptive immunity
G Bonizzi et al.
TRENDS IN IMMUNOLOGY (2004)
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5
DS Cai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
SE Shoelson et al.
INTERNATIONAL JOURNAL OF OBESITY (2003)
The forkhead transcription factor Foxo1 regulates adipocyte differentiation
J Nakae et al.
DEVELOPMENTAL CELL (2003)
Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
ZG Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
M Björnholm et al.
DIABETOLOGIA (2002)
A central role for JNK in obesity and insulin resistance
J Hirosumi et al.
NATURE (2002)
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
M Frödin et al.
EMBO JOURNAL (2002)
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
M Blüher et al.
DEVELOPMENTAL CELL (2002)
Effects of TNF-alpha on glucose metabolism and lipolysis in adipose tissue and isolated fat-cell preparations
MH Porter et al.
JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2002)
Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel et al.
NATURE (2001)
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
MS Yuan et al.
SCIENCE (2001)
Hyperinsulinemia enhances transcriptional activity of nuclear factor-κB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells
I Golovchenko et al.
CIRCULATION RESEARCH (2000)
Signalling pathways - Kinase regulation in inflammatory response
M Delhase et al.
NATURE (2000)
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
V Aguirre et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
